6LoWPAN Stack Model Configuration for IoT Streaming Data Transmission over CoAP

Abstract: Different protocols have been developed for the Internet of things (IoT), such as the constrained application protocol (CoAP) for the application layer of the IPv6 over low-power wireless personal area networks (6LoWPAN) stack model. Data transmitted over 6LoWPAN are limited by the throughput and the frame size defined by IEEE 805.14.5 standards. Choosing the best configuration for data transmission involves a trade off between the application requirements, the constrained network configuration, the constrained device specifications and IoT application protocols. This paper provides an analysis of message size and structure recommendations for the 6LoWPAN stack model for different network topologies using CoAP. CoAP is a promising application protocol for the 6LoWPAN stack model because it can effectively manage the transmission required functionality in small header UDP packets compared to TCP packets. However, a data model is also required to realize an effective IoT model. While fragmentation and reassembly are supported by CoAP, they should be avoided for this type of model. As for any conceptual model, a high configuration between layers is mandatory. Additionally, the proposed message format is useful for semantic web of things application development and for WSN design and management

Treatment of Hypertensive Crisis Using Beta Blockers Vs Diuretics: Review

Current review aiming to evaluate and the advantage and disadvantage and also to discuss the differences in use and combination therapy of beta blockers VS diuretics in the treatment of hypertensive crisis.  Literature were search on topic concerning the treatment of hypertensive crisis, using biomedical databases; PubMed, and Embase, up to August, 2017.  Patients with hypertensive crises could call for immediate reduction in raised high blood pressure to stop and also detain modern end-organ damage. The best scientific setup in which to attain this blood pressure control remains in the intensive care unit, with making use of titratable intravenous hypotensive agents. Beta-blocker- based therapy, numerous possible randomized trials have recorded that diuretic-based treatment is efficient in reducing morbidity and also mortality in hypertensive patients. The advantages of diuretic therapy have actually been shown to be more significant in the senior compared to in younger patients. The result of diuretics is especially articulated when it comes to decrease of the risk of stroke and also somewhat less excellent with regard to the reduction of the danger of coronary heart disease. Keywords: Hypertension, Diuretics Therapy, Beta Blocker, Hypertensive Crisis

Therapeutic effects of Crataegus monogyna inhibitors against breast cancer

Breast cancer is a silent killer disorder among women and a serious economic burden in healthcare management. Every 19 s, a woman is diagnosed with breast cancer, and every 74 s, a woman worldwide passes away from the disease. Despite the increase in progressive research, advanced treatment approaches, and preventive measures, breast cancer rates continue to increase. This study provides a combination of data mining, network pharmacology, and docking analysis that surely could revolutionize cancer treatment by exploiting prestigious phytochemicals. Crataegus monogyna is a small, rounded deciduous tree with glossy, deeply lobed leaves and flat sprays of cream flowers, followed by dark red berries in autumn. Various studies demonstrated that C. monogyna is therapeutically effective against breast cancer. However, the particular molecular mechanism is still unknown. This study is credited for locating bioactive substances, metabolic pathways, and target genes for breast cancer treatment. According to the current investigation, which examined compound–target genes–pathway networks, it was found that the bioactive compounds of C. monogyna may operate as a viable solution against breast cancer by altering the target genes implicated in the disease pathogenesis. The expression level of target genes was analyzed using GSE36295 microarray data. Docking analysis and molecular dynamic simulation studies further strengthened the current findings by validating the effective activity of the bioactive compounds against putative target genes. In summary, we propose that six key compounds, luteolin, apigenin, quercetin, kaempferol, ursolic acid, and oleanolic acid, contributed to the development of breast cancer by affecting the MMP9 and PPARG proteins. Integration of network pharmacology and bioinformatics revealed C. monogyna’s multitarget pharmacological mechanisms against breast cancer. This study provides convincing evidence that C. monogyna might partially alleviate breast cancer and ultimately lays a foundation for further experimental research on the anti-breast cancer activity of C. monogyna

Coronary Artery Bypass grafting (CABG) versus Percutaneous Coronary Intervention (PCI) in the treatment of multivessel coronary disease

BackgroundRevascularization for patients who suffer multivessel coronary artery disease is a common procedure around the world. Taking United about 700,000 patients have multivessel coronary revascularization per year ¼ of these patients are diagnosed with diabetes. AimsTo summarize the current evidence that compare CABG to PCI in multivessel coronary disease‎ in form of ‎cardiac death, stroke, MI and unplanned devascularization.‎Methods This is a systematic review was carried out, including PubMed, Google Scholar, and EBSCO that examining randomized trials of treatment of multivessel coronary disease to summarize the major RCT concerning this topic.Results The review included five randomized studies that compare coronary artery bypass grafting and percutaneous coronary intervention. The findings showed that CABG show better result with less mortality rate.ConclusionThis review concluded that there revascularization in treating coronary artery disease could be conducted either by CABG or PCI, CABG show better result as it cause less death, MI and revascularization rates, but the usage of new additions such as second generation DES, can also improve the safety and efficacy of PCI when added to it

A new biologically-inspired analytical worm propagation model for mobile unstructured peer-to-peer networks

Millions of users world-wide are sharing content using the Peer-to-Peer (P2P) client network. While new innovations bring benefits, there are nevertheless some dangers associated with them. One of the main threats is P2P worms that can penetrate the network even from a single node and can then spread very quickly. Many attempts have been made in this domain to model the worm propagation behaviour, and yet no single model exists that can realistically model the process. Most researchers have considered disease epidemic models for modelling the worm propagation process. Such models are, however, based on strong assumptions which may not necessarily be valid in real-world scenarios. In this paper, a new biologically-inspired analytical model is proposed, one that considers configuration diversity, infection time lag, user-behaviour and node mobility as the important parameters that affect the worm propagation process. The model is flexible and can represent a network where all nodes are mobile or a heterogeneous network, where some nodes are static and others are mobile. A complete derivation of each of the factors is provided in the analytical model, and the results are benchmarked against recently reported analytical models. A comparative analysis of simulation results indeed shows that our proposed biologically-inspired model represents a more realistic picture of the worm propagation process, compared to the existing state-of-the-art analytical models

Pressure vessel design simulation using hybrid harmony search algorithm

Recently the development of optimization algorithm is rapidly increased. Among several optimization algorithms, Harmony Search (HS) has been recently proposed for solving engineering optimization problems. The HS has some weaknesses such as parameters selection and falling in local optima. Many variants proposed to solve these problems. This paper presents successful hybrid algorithms with high performance to solve the pressure vessel design simulation. The hybrid algorithms consist of well-known variants of HS and an opposition-based learning technique. The hybrid algorithm improved the HS exploration and avoiding falling in local optima, which lead the algorithm to provide significant results

Rational design of Pd-TiO2/g-C3N4 heterojunction with enhanced photocatalytic activity through interfacial charge transfer

A hybrid heterojunction-based photocatalyst is synthesized by an electrostatic self-assembly strategy including surface modification and controlled metal deposition. The interfacial contact was made by mixing negatively charged anatase TiO2 nanoparticles with positively charged g-C3N4. Visible-light deposition of Pd nanoparticles largely on TiO2 was made possible due to the charge transfer from C3N4 (excited by visible light) to the conduction band of TiO2 reducing Pd ions on contact with its surface. In order to further test the efficiency of this cascade of electron transfer across the conduction bands of the two semiconductors, photocatalytic H2 production from water was studied. Upon optimizing the ratio of the two semiconductors, increased H2 production rates were observed and attributed to enhanced charge separation. Catalysts were studied by a variety of techniques in order to probe into their properties and link them to activity. The reaction rate, under visible-light excitation, of the best sample showed an 8-fold enhancement when compared to that of Pd-C3N4 in identical conditions and the highest apparent quantum yield of 31% was achieved by a 0.1%Pd/20%TiO2/C3N4 sample in a 420- to 443-nm range